Humanin gene expression in fibroblast of Down syndrome subjects.
Int J Med Sci
; 17(3): 320-324, 2020.
Article
em En
| MEDLINE
| ID: mdl-32132866
ABSTRACT
Down syndrome (DS) is characterized by trisomy of chromosome 21 and peculiar phenotype. Humanin (HN) is a mitochondrial short 24-residue polypeptide whit anti-apoptotic and neuroprotective effects. In this study we evaluated HN protein expression and HN mRNA levels in cultured fibroblasts from DS patients and normal controls. Our results obtained by immunocytochemistry, western-blot and qRT-PCR analysis show a significant HN up-regulation in DS patients. These results confirm previous studies and suggest a role for HN may in the DS phenotype.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Síndrome de Down
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article