Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-&#954;B signaling pathway in vivo and in vitro.

Yan, Shichang; Ding, Huimin; Peng, Junyang; Wang, Xinqiang; Pang, Chenglong; Wei, Juncheng; Wei, Jianjun; Chen, Hui

Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-κB signaling pathway in vivo and in vitro.

Yan, Shichang; Ding, Huimin; Peng, Junyang; Wang, Xinqiang; Pang, Chenglong; Wei, Juncheng; Wei, Jianjun; Chen, Hui.

Afiliação

Yan S; Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China.
Ding H; Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China.
Peng J; Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China.
Wang X; Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China.
Pang C; Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China.
Wei J; Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China.
Wei J; Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China.
Chen H; Department of Orthopaedic, BenQ Medical Center, The Affilicated BenQ Hospital of Nanjing Medical University, 210019, Nanjing, Jiangsu Province, China.

Biosci Rep ; 40(3)2020 03 27.

Article em En | MEDLINE | ID: mdl-32134473

Assuntos

Osteoartrite/metabolismo; Receptor PAR-2/metabolismo; Animais; China; Condrócitos/metabolismo; Ciclo-Oxigenase 2/metabolismo; Feminino; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Metaloproteinase 1 da Matriz/metabolismo; Metaloproteinase 13 da Matriz/metabolismo; NF-kappa B/genética; Osteoartrite/fisiopatologia; Ratos; Ratos Sprague-Dawley; Receptor PAR-2/antagonistas & inibidores; Receptor PAR-2/genética; Transdução de Sinais/efeitos dos fármacos; Fator de Necrose Tumoral alfa/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo

Palavras-chave

Autophagy; MAPK/NF-kB signaling pathway; Osteoarthritis; Protease-activated receptor 2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite / Receptor PAR-2 Limite: Animals País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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