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Boosting Cytotoxic Antibodies against Cancer.
Gauthier, Laurent; Vivier, Eric.
Afiliação
  • Gauthier L; Innate Pharma Research Laboratories, Innate Pharma, Marseille, France. Electronic address: laurent.gauthier@innate-pharma.fr.
  • Vivier E; Innate Pharma Research Laboratories, Innate Pharma, Marseille, France; Aix Marseille Université, CNRS, INSERM, CIML, Marseille, France; APHM, Hôpital de la Timone, Service d'Immunologie, Marseille-Immunopôle, Marseille, France.
Cell ; 180(5): 822-824, 2020 03 05.
Article em En | MEDLINE | ID: mdl-32142673
Monoclonal antibodies (mAbs) targeting antigens expressed at the surface of tumor cells are widely used for cancer control in clinics, but these treatments need to be improved. Chew et al. show how an old drug, prochlorperazine, could be repurposed to enhance the efficacy of anti-tumor mAbs by increasing the cell-surface expression of tumor antigens.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citotoxicidade Celular Dependente de Anticorpos / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citotoxicidade Celular Dependente de Anticorpos / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article