Evaluation of a smart activatable MRI nanoprobe to target matrix metalloproteinases in the early-stages of abdominal aortic aneurysms.
Nanomedicine
; 26: 102177, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32142755
ABSTRACT
Matrix metalloproteinases (MMPs) activation contributes to abdominal aortic aneurysm (AAA) growth and rupture. The study was to evaluate the ability of a novel activatable magnetic resonance imaging (MRI) nanoprobe, to target MMPs in an Angiotensin II (ANG II)-induced AAA model. The activatable nanoprobe is composed of a hydrophilic polyethylene glycol coating layer immobilized on the external surface of core/shell Fe/iron oxide nanoparticles; between them, there was grafted the MMP peptide substrate. In the ANG II infusion mice model of AAAs, MRI was performed to characterize the progression of model. The contrast-to-noise ratio was lower in the aneurysm of the mice injected with activatable nanoprobe. Histological studies revealed the presence of MMPs and iron-oxide in regions of MR signal decrease. MRI combined with nanoprobe allows the detection of MMP activity within the wall of AAA, thus representing a potential noninvasive method to predict the rupture risk of AAA.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
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Aneurisma da Aorta Abdominal
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Metaloproteinases da Matriz
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Nanopartículas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article