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An analytical theory of balanced cellular growth.
Dourado, Hugo; Lercher, Martin J.
Afiliação
  • Dourado H; Institute for Computer Science & Department of Biology, Heinrich Heine University, 40221, Düsseldorf, Germany.
  • Lercher MJ; Institute for Computer Science & Department of Biology, Heinrich Heine University, 40221, Düsseldorf, Germany. martin.lercher@hhu.de.
Nat Commun ; 11(1): 1226, 2020 03 06.
Article em En | MEDLINE | ID: mdl-32144263
ABSTRACT
The biological fitness of microbes is largely determined by the rate with which they replicate their biomass composition. Mathematical models that maximize this balanced growth rate while accounting for mass conservation, reaction kinetics, and limits on dry mass per volume are inevitably non-linear. Here, we develop a general theory for such models, termed Growth Balance Analysis (GBA), which provides explicit expressions for protein concentrations, fluxes, and growth rates. These variables are functions of the concentrations of cellular components, for which we calculate marginal fitness costs and benefits that are related to metabolic control coefficients. At maximal growth rate, the net benefits of all concentrations are equal. Based solely on physicochemical constraints, GBA unveils fundamental quantitative principles of cellular resource allocation and growth; it accurately predicts the relationship between growth rates and ribosome concentrations in E. coli and yeast and between growth rate and dry mass density in E. coli.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proliferação de Células / Escherichia coli / Modelos Biológicos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proliferação de Células / Escherichia coli / Modelos Biológicos Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article