Your browser doesn't support javascript.
loading
Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice.
Matsui, Kazuki; Terada, Yuka; Tsubota, Maho; Sekiguchi, Fumiko; Kawabata, Atsufumi.
Afiliação
  • Matsui K; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
  • Terada Y; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
  • Tsubota M; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
  • Sekiguchi F; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan.
  • Kawabata A; Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Japan. Electronic address: kawabata@phar.kindai.ac.jp.
J Pharmacol Sci ; 143(1): 60-63, 2020 May.
Article em En | MEDLINE | ID: mdl-32151541
TRPV1 is phosphorylated and functionally upregulated by protein kinases, and negatively regulated by phosphatases including calcineurin. Since the clinical use of calcineurin-inhibiting immunosuppressants is commonly associated with chronic diarrhea, we examined if tacrolimus, a calcineurin inhibitor, promotes TRPV1-dependent colonic hypersensitivity in mice. Intracolonic administration of capsaicin, a TRPV1 agonist, caused referred hyperalgesia in the lower abdomen, an effect prevented by capsazepine, a TRPV1 blocker. Tacrolimus accelerated the intracolonic capsaicin-induced referred hyperalgesia. Similarly, intracolonic capsaicin caused spinal ERK phosphorylation, a marker for nociceptor excitation, an effect promoted by tacrolimus. Thus, tacrolimus may aggravate TRPV1-related colonic pain accompanying irritable bowel syndrome.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Capsaicina / Tacrolimo / Colo / Inibidores de Calcineurina / Hiperalgesia / Imunossupressores Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Capsaicina / Tacrolimo / Colo / Inibidores de Calcineurina / Hiperalgesia / Imunossupressores Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article