Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target.

Xiong, Xiao; Ke, Xiurong; Wang, Lu; Yao, Zhimeng; Guo, Yi; Zhang, Xianyang; Chen, Yuping; Pang, Chi Pui; Schally, Andrew V; Zhang, Hao

Xiong, Xiao; Ke, Xiurong; Wang, Lu; Yao, Zhimeng; Guo, Yi; Zhang, Xianyang; Chen, Yuping; Pang, Chi Pui; Schally, Andrew V; Zhang, Hao.

Afiliação

Xiong X; Department of General Surgery, First Affiliated Hospital of Jinan University, 510632 Guangzhou, Guangdong, China.
Ke X; Institute of Precision Cancer Medicine and Pathology, Jinan University Medical College, 510632 Guangzhou, Guangdong, China.
Wang L; Department of Immunotherapy and Gastrointestinal Oncology, Affiliated Cancer Hospital of Shantou University Medical College, 515041 Shantou, Guangdong, China.
Yao Z; Department of Surgery, Translational Surgical Oncology, University Medical Center Groningen, University of Groningen, GZ 9713 Groningen, The Netherlands.
Guo Y; Department of General Surgery, First Affiliated Hospital of Jinan University, 510632 Guangzhou, Guangdong, China.
Zhang X; Institute of Precision Cancer Medicine and Pathology, Jinan University Medical College, 510632 Guangzhou, Guangdong, China.
Chen Y; Department of General Surgery, First Affiliated Hospital of Jinan University, 510632 Guangzhou, Guangdong, China.
Pang CP; Institute of Precision Cancer Medicine and Pathology, Jinan University Medical College, 510632 Guangzhou, Guangdong, China.
Schally AV; Department of Immunotherapy and Gastrointestinal Oncology, Affiliated Cancer Hospital of Shantou University Medical College, 515041 Shantou, Guangdong, China.
Zhang H; Endoscopy Center, Affiliated Cancer Hospital of Shantou University Medical College, 515041 Shantou, Guangdong, China.

Proc Natl Acad Sci U S A ; 117(12): 6726-6732, 2020 03 24.

Article em En | MEDLINE | ID: mdl-32156725

Assuntos

Biomarcadores Tumorais/genética; Neoplasias Esofágicas/patologia; Carcinoma de Células Escamosas do Esôfago/patologia; Regulação Neoplásica da Expressão Gênica; Receptores LHRH/genética; Sermorelina/análogos & derivados; Processamento Alternativo; Animais; Apoptose; Proliferação de Células; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/metabolismo; Carcinoma de Células Escamosas do Esôfago/genética; Carcinoma de Células Escamosas do Esôfago/metabolismo; Feminino; Glicólise; Humanos; Camundongos; Camundongos Nus; NF-kappa B/genética; NF-kappa B/metabolismo; Fosfofrutoquinase-1 Muscular/genética; Fosfofrutoquinase-1 Muscular/metabolismo; Receptores LHRH/antagonistas & inibidores; Sermorelina/farmacologia; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

GHRH-R antagonist; PFKM; glycolysis; hypoxia; splicing isoform of GHRH-R

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Sermorelina / Receptores LHRH / Carcinoma de Células Escamosas do Esôfago Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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