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CD11c+ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors.
Golinski, Marie-Laure; Demeules, Mélanie; Derambure, Céline; Riou, Gaetan; Maho-Vaillant, Maud; Boyer, Olivier; Joly, Pascal; Calbo, Sébastien.
Afiliação
  • Golinski ML; INSERM U1234, Normandy University, Rouen, France.
  • Demeules M; Department of Dermatology, Rouen University Hospital, Rouen, France.
  • Derambure C; INSERM U1234, Normandy University, Rouen, France.
  • Riou G; INSERM U1245, Normandy University, Rouen, France.
  • Maho-Vaillant M; INSERM U1234, Normandy University, Rouen, France.
  • Boyer O; INSERM U1234, Normandy University, Rouen, France.
  • Joly P; Department of Dermatology, Rouen University Hospital, Rouen, France.
  • Calbo S; INSERM U1234, Normandy University, Rouen, France.
Front Immunol ; 11: 32, 2020.
Article em En | MEDLINE | ID: mdl-32158442
CD11c+ B cells have been reported to be increased in autoimmune diseases, but they are detected in the blood of healthy individuals as well. We aimed to characterize CD11c+ B cells from healthy donors by flow cytometry, microarray analysis, and in vitro functional assays. Here, we report that CD11c+ B cells are a distinct subpopulation of B cells, enriched in the memory subpopulation even if their phenotype is heterogeneous, with overexpression of genes involved in B-cell activation and differentiation as well as in antigen presentation. Upon activation, CD11c+ B cells can differentiate into antibody-secreting cells, and CD11c could be upregulated in CD11c- B cells by B-cell receptor activation. Finally, we show that patients with pemphigus, an autoimmune disease mediated by B cells, have a decreased frequency of CD11c+ B cell after treatment, relative to baseline. Our findings show that CD11c+ B cells are mainly memory B cells prone to differentiate into antibody secreting cells that accumulate with age, independently of gender.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmócitos / Receptores de Antígenos de Linfócitos B / Diferenciação Celular / Antígeno CD11c / Memória Imunológica Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmócitos / Receptores de Antígenos de Linfócitos B / Diferenciação Celular / Antígeno CD11c / Memória Imunológica Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article