Transcription-dependent DNA double-strand breaks and human disease.
Mol Cell Oncol
; 7(2): 1691905, 2020.
Article
em En
| MEDLINE
| ID: mdl-32158914
ABSTRACT
Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article