Melanocortin therapy ameliorates podocytopathy and proteinuria in experimental focal segmental glomerulosclerosis involving a podocyte specific non-MC1R-mediated melanocortinergic signaling.

Qiao, Yingjin; Wang, Pei; Chang, Mingyang; Chen, Bohan; Ge, Yan; Malhotra, Deepak K; Dworkin, Lance D; Gong, Rujun

Qiao, Yingjin; Wang, Pei; Chang, Mingyang; Chen, Bohan; Ge, Yan; Malhotra, Deepak K; Dworkin, Lance D; Gong, Rujun.

Afiliação

Qiao Y; Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, U.S.A.
Wang P; Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, U.S.A.
Chang M; Institute of Nephrology, Blood Purification Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chen B; Division of Nephrology, University of Toledo College of Medicine, Toledo, Ohio, U.S.A.
Ge Y; Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, U.S.A.
Malhotra DK; Division of Nephrology, University of Toledo College of Medicine, Toledo, Ohio, U.S.A.
Dworkin LD; Division of Kidney Disease and Hypertension, Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, U.S.A.
Gong R; Division of Nephrology, University of Toledo College of Medicine, Toledo, Ohio, U.S.A.

Clin Sci (Lond) ; 134(7): 695-710, 2020 04 17.

Article em En | MEDLINE | ID: mdl-32167144

Assuntos

Albuminúria/prevenção & controle; Apoptose/efeitos dos fármacos; Glomerulosclerose Segmentar e Focal/prevenção & controle; Podócitos/efeitos dos fármacos; Receptor Tipo 1 de Melanocortina/agonistas; alfa-MSH/análogos & derivados; Albuminúria/induzido quimicamente; Albuminúria/metabolismo; Albuminúria/patologia; Animais; Movimento Celular/efeitos dos fármacos; Células Cultivadas; Modelos Animais de Doenças; Doxorrubicina; Glomerulosclerose Segmentar e Focal/induzido quimicamente; Glomerulosclerose Segmentar e Focal/metabolismo; Glomerulosclerose Segmentar e Focal/patologia; Camundongos Endogâmicos C57BL; Camundongos Knockout; Permeabilidade; Podócitos/metabolismo; Podócitos/ultraestrutura; Receptor Tipo 1 de Melanocortina/genética; Receptor Tipo 1 de Melanocortina/metabolismo; Transdução de Sinais; alfa-MSH/farmacologia

Palavras-chave

adrenocorticotropic hormone; apoptosis; cytoskeleton; glomerular disease; podocytes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Alfa-MSH / Glomerulosclerose Segmentar e Focal / Apoptose / Receptor Tipo 1 de Melanocortina / Albuminúria / Podócitos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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