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Air pollution and hippocampal atrophy in first episode schizophrenia.
Worthington, Michelle A; Petkova, Eva; Freudenreich, Oliver; Cather, Corrine; Holt, Daphne; Bello, Iruma; Diminich, Erica; Tang, Yingying; Ardekani, Babak A; Zeng, Botao; Wu, Renrong; Fan, Xiaoduo; Zhao, Jingping; Wang, Jijun; Goff, Donald C.
Afiliação
  • Worthington MA; Department of Psychology, Yale University, New Haven, CT, United States of America.
  • Petkova E; NYU Langone Health Department of Population Health, New York, NY, United States of America; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, United States of America.
  • Freudenreich O; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
  • Cather C; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
  • Holt D; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
  • Bello I; New York State Psychiatric Institute, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States of America.
  • Diminich E; Department of Psychiatry, Stony Brook School of Medicine, Stony Brook, NY, United States of America.
  • Tang Y; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Ardekani BA; NYU Langone Health Department of Psychiatry, New York, NY, United States of America; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, United States of America.
  • Zeng B; Department of Psychiatry, Qingdao Mental Health Center, Qingdao, China.
  • Wu R; National Clinical Research Center for Mental Disorders, Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
  • Fan X; Department of Psychiatry, University of Massachusetts Medical Center, Worcester, MA, United States of America.
  • Zhao J; National Clinical Research Center for Mental Disorders, Mental Health Institute, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
  • Wang J; Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Goff DC; NYU Langone Health Department of Psychiatry, New York, NY, United States of America; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, United States of America. Electronic address: Donald.Goff@nyulangone.org.
Schizophr Res ; 218: 63-69, 2020 04.
Article em En | MEDLINE | ID: mdl-32169403
Air pollution has recently been linked to central nervous system (CNS) diseases, possibly mediated by inflammation and oxidative stress. Hippocampal atrophy in individuals with first episode schizophrenia (FES) has also been associated with biomarkers of inflammation and oxidative stress, whereas hippocampal atrophy was not observed in matched healthy controls with similar biomarker levels of inflammation and oxidative stress. Fine particulate matter (PM2.5), one component of air pollution, is most strongly implicated in CNS disease. The present study examined the association between PM2.5 and hippocampal volume in individuals with FES who participated in a 52-week placebo-controlled clinical trial of citalopram added to clinician-determined antipsychotic treatment at four sites in the US and China. Left hippocampal volumetric integrity (LHVI; inversely related to atrophy) was measured at baseline and week 52 using an automated highly-reliable algorithm. Mean annual PM2.5 concentrations were obtained from records compiled by the World Health Organization. The relationships between baseline LHVI and PM2.5 and change in LHVI and PM2.5 were evaluated using regression analyses. 89 participants completed imaging at baseline and 46 participants completed imaging at week 52. Mean annual PM2.5 was significantly associated with both baseline LHVI and change in LHVI after controlling for age, sex, baseline LHVI, duration of untreated psychosis and baseline antipsychotic medication dose. Air pollution may contribute to the progression of hippocampal atrophy after a first episode of illness, but these findings should be considered preliminary since other unmeasured factors may have differed between cities and contributed to the observed effect.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Poluição do Ar Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Poluição do Ar Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article