Gegen Qinlian Decoction abates nonalcoholic steatohepatitis associated liver injuries via anti-oxidative stress and anti-inflammatory response involved inhibition of toll-like receptor 4 signaling pathways.

Zhang, Chang-Hua; Xiao, Qin; Sheng, Jun-Qing; Liu, Tong-Tong; Cao, Ying-Qian; Xue, Ya-Nan; Shi, Min; Cao, Zheng; Zhou, Li-Fen; Luo, Xiao-Quan; Deng, Ke-Zhong; Chen, Chen

Zhang, Chang-Hua; Xiao, Qin; Sheng, Jun-Qing; Liu, Tong-Tong; Cao, Ying-Qian; Xue, Ya-Nan; Shi, Min; Cao, Zheng; Zhou, Li-Fen; Luo, Xiao-Quan; Deng, Ke-Zhong; Chen, Chen.

Afiliação

Zhang CH; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Xiao Q; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Sheng JQ; College of Life Science, Nanchang University, Nanchang, 330031, PR China. Electronic address: shengjunqin@163.com.
Liu TT; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Cao YQ; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Xue YN; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Shi M; College of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Cao Z; College of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Zhou LF; Large Precise Instruments Shared Services Center of TCM, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Luo XQ; Experimental Animal Science and Technology Center of TCM, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi 330004, PR China.
Deng KZ; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, 330004, PR China.
Chen C; School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia. Electronic address: chen.chen@uq.edu.au.

Biomed Pharmacother ; 126: 110076, 2020 Jun.

Article em En | MEDLINE | ID: mdl-32169759

Assuntos

Anti-Inflamatórios/farmacologia; Antioxidantes/farmacologia; Medicamentos de Ervas Chinesas/farmacologia; Hepatopatia Gordurosa não Alcoólica/etiologia; Hepatopatia Gordurosa não Alcoólica/metabolismo; Transdução de Sinais/efeitos dos fármacos; Receptor 4 Toll-Like/metabolismo; Animais; Biomarcadores; Linhagem Celular; Citocinas/metabolismo; Modelos Animais de Doenças; Feminino; Perfilação da Expressão Gênica; Mediadores da Inflamação/metabolismo; Metabolismo dos Lipídeos/efeitos dos fármacos; Lipopolissacarídeos/imunologia; Camundongos; Modelos Biológicos; Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico; Hepatopatia Gordurosa não Alcoólica/patologia; Estresse Oxidativo/efeitos dos fármacos; Proteômica/métodos; Ratos; Transcriptoma

Palavras-chave

Gegen Qinlian Decoction; Hepatic lipid metabolism; Inflammation; Non-alcoholic steatohepatitis; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Transdução de Sinais / Receptor 4 Toll-Like / Hepatopatia Gordurosa não Alcoólica / Anti-Inflamatórios / Antioxidantes Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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