Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice.

You, Dahea; Lyn-Cook, Lascelles E; Gatti, Daniel M; Bell, Natalie; Mayeux, Philip R; James, Laura P; Mattes, William B; Larson, Gary J; Harrill, Alison H

You, Dahea; Lyn-Cook, Lascelles E; Gatti, Daniel M; Bell, Natalie; Mayeux, Philip R; James, Laura P; Mattes, William B; Larson, Gary J; Harrill, Alison H.

Afiliação

You D; Division of the National Toxicology Program, The National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Lyn-Cook LE; Graduate Program in Interdisciplinary Biomedical Sciences, The University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, Arkansas 72205.
Gatti DM; The Jackson Laboratory, Bar Harbor, Maine 04609.
Bell N; Division of the National Toxicology Program, The National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Mayeux PR; East Carolina University, Greenville, North Carolina 27858.
James LP; Department of Pharmacology and Toxicology.
Mattes WB; Department of Pediatrics, The University of Arkansas for Medical Sciences and Arkansas Children's Research Institute, Little Rock, Arkansas 27705.
Larson GJ; Division of Systems Biology, The National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079.
Harrill AH; Social & Scientific Systems, Inc., Durham, North Carolina 27703.

Toxicol Sci ; 175(2): 220-235, 2020 06 01.

Article em En | MEDLINE | ID: mdl-32170957

Assuntos

Doença Hepática Induzida por Substâncias e Drogas/fisiopatologia; Predisposição Genética para Doença; Homeostase/efeitos dos fármacos; Hidroxiureia/toxicidade; Lipídeos/biossíntese; Estresse Nitrosativo/efeitos dos fármacos; Estresse Fisiológico/efeitos dos fármacos; Animais; Antiasmáticos/toxicidade; Asma/tratamento farmacológico; Camundongos de Cruzamento Colaborativo; Modelos Animais de Doenças; Feminino; Camundongos

Palavras-chave

Diversity Outbred; drug-induced liver injury; genetic variability; idiosyncratic hepatotoxicity; zileuton

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Predisposição Genética para Doença / Doença Hepática Induzida por Substâncias e Drogas / Estresse Nitrosativo / Homeostase / Hidroxiureia / Lipídeos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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