Selective cytotoxic activity and protective effects of sodium ascorbate against hepatocellular carcinoma through its effect on oxidative stress and apoptosis <i>in vivo</i> and <i>in vitro</i>.

El-Far, Yousra M; Khodir, Ahmed E; Noor, Ahmad O; Almasri, Deina M; Bagalagel, Alaa A; Diri, Reem M; Kutbi, Hussam I; Al-Gayyar, Mohammed M H

Selective cytotoxic activity and protective effects of sodium ascorbate against hepatocellular carcinoma through its effect on oxidative stress and apoptosis in vivo and in vitro.

El-Far, Yousra M; Khodir, Ahmed E; Noor, Ahmad O; Almasri, Deina M; Bagalagel, Alaa A; Diri, Reem M; Kutbi, Hussam I; Al-Gayyar, Mohammed M H.

Afiliação

El-Far YM; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Khodir AE; Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa City, Mansoura, Dakhliya, Egypt.
Noor AO; Deparment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Almasri DM; Deparment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Bagalagel AA; Deparment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Diri RM; Deparment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Kutbi HI; Deparment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Al-Gayyar MMH; Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Redox Rep ; 25(1): 17-25, 2020 Dec.

Article em En | MEDLINE | ID: mdl-32172678

Assuntos

Antineoplásicos/farmacologia; Apoptose; Ácido Ascórbico/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Neoplasias Hepáticas Experimentais/tratamento farmacológico; Estresse Oxidativo; Substâncias Protetoras/farmacologia; Animais; Antioxidantes/farmacologia; Carcinoma Hepatocelular/induzido quimicamente; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Células Hep G2; Humanos; Neoplasias Hepáticas Experimentais/induzido quimicamente; Neoplasias Hepáticas Experimentais/metabolismo; Neoplasias Hepáticas Experimentais/patologia; Masculino; Ratos; Ratos Sprague-Dawley; Tioacetamida/toxicidade

Palavras-chave

Caspase-3/8/9; HepG2; hydrogen peroxide; nuclear factor (NF)κB; nuclear factor erythroid 2 related factor (Nrf2)|; sodium ascorbate|; superoxide anion|; tumor necrosis factor (TNF)-α

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Ascórbico / Apoptose / Carcinoma Hepatocelular / Estresse Oxidativo / Substâncias Protetoras / Neoplasias Hepáticas Experimentais / Antineoplásicos Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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