Structural characterization of a heteropolysaccharide from fruit of Chaenomelese speciosa (Sweet) Nakai and its antitumor activity.
Carbohydr Polym
; 236: 116065, 2020 May 15.
Article
em En
| MEDLINE
| ID: mdl-32172880
ABSTRACT
The present study aimed at investigating the structural features and antitumor properties of a novel heteropolysaccharide (CSP-W-2) obtained from the fruit of Chaenomeles Speciosa (Sweet) Nakai. CSP-W-2 demonstrate that they mainly contain glucose, galactose, arabinose, mannose, xylose in a ratio of 3.7 3.2 1.7 0.9 0.4, with the molecular weight of 8.7â¯kDa. Its backbone is predominantly composed of 1,4 linked ß-D-Galp, 1,4 linked α-D-Glcp, 1,4 linked ß-D-Glcp, and 1,4,6-ß-D-Glcp, additionally some branches contained 1,5 linked α-L-Araf, 1,4 linked ß-D-Glcp, 1,3 linked α-L-Araf, and T linked ß-D-Manp according to the results of partial acid hydrolysis analysis, methylation analysis, IR and NMR spectra. The antitumor properties study results demonstrated that CSP-W-2â¯had an inhibitory effect on HepG2 growth by enhancing the nucleus shrinkage and apoptosis. These findings indicate that CSP-W-2â¯had antitumor potential in the treatment of human liver tumor.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article