Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory.

Chan, Kelvin; Nestor, Jacquelyn; Huerta, Tomás S; Certain, Noele; Moody, Gabrielle; Kowal, Czeslawa; Huerta, Patricio T; Volpe, Bruce T; Diamond, Betty; Wollmuth, Lonnie P

Chan, Kelvin; Nestor, Jacquelyn; Huerta, Tomás S; Certain, Noele; Moody, Gabrielle; Kowal, Czeslawa; Huerta, Patricio T; Volpe, Bruce T; Diamond, Betty; Wollmuth, Lonnie P.

Afiliação

Chan K; Graduate Program in Neuroscience, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Nestor J; Medical Scientist Training Program (MSTP), Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Huerta TS; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Certain N; Donald & Barbara Zucker School of Medicine, Hofstra University, Hempstead, NY, 11549, USA.
Moody G; Center for Autoimmune, Musculoskeletal and Hematopoietic Diseases, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, 11030, USA.
Kowal C; Donald & Barbara Zucker School of Medicine, Hofstra University, Hempstead, NY, 11549, USA.
Huerta PT; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Volpe BT; Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Diamond B; Department of Neurobiology & Behavior, Stony Brook University, Stony Brook, NY, 11794-5230, USA.
Wollmuth LP; Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, NY, 11794-5230, USA.

Nat Commun ; 11(1): 1403, 2020 03 16.

Article em En | MEDLINE | ID: mdl-32179753

Assuntos

Autoanticorpos/imunologia; Lúpus Eritematoso Sistêmico/imunologia; Lúpus Eritematoso Sistêmico/psicologia; Receptores de N-Metil-D-Aspartato/imunologia; Memória Espacial; Animais; Morte Celular; Feminino; Humanos; Lúpus Eritematoso Sistêmico/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Neurônios/citologia; Neurônios/imunologia; Receptores de N-Metil-D-Aspartato/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoanticorpos / Receptores de N-Metil-D-Aspartato / Memória Espacial / Lúpus Eritematoso Sistêmico Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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