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Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications.
Goydel, Rebecca S; Weber, Justus; Peng, Haiyong; Qi, Junpeng; Soden, Jo; Freeth, Jim; Park, HaJeung; Rader, Christoph.
Afiliação
  • Goydel RS; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida 33458.
  • Weber J; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida 33458.
  • Peng H; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida 33458.
  • Qi J; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida 33458.
  • Soden J; Retrogenix Ltd., Chinley, High Peak SK23 6FJ, United Kingdom.
  • Freeth J; Retrogenix Ltd., Chinley, High Peak SK23 6FJ, United Kingdom.
  • Park H; X-Ray Crystallography Core, The Scripps Research Institute, Jupiter, Florida 33458.
  • Rader C; Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida 33458. Electronic address: crader@scripps.edu.
J Biol Chem ; 295(18): 5995-6006, 2020 05 01.
Article em En | MEDLINE | ID: mdl-32193207

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Órfãos Semelhantes a Receptor Tirosina Quinase / Anticorpos Monoclonais Humanizados / Afinidade de Anticorpos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Órfãos Semelhantes a Receptor Tirosina Quinase / Anticorpos Monoclonais Humanizados / Afinidade de Anticorpos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article