Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli.

Li, Guangbi; Kidd, Jason; Kaspar, Cristin; Dempsey, Sara; Bhat, Owais M; Camus, Sarah; Ritter, Joseph K; Gehr, Todd W B; Gulbins, Erich; Li, Pin-Lan

Li, Guangbi; Kidd, Jason; Kaspar, Cristin; Dempsey, Sara; Bhat, Owais M; Camus, Sarah; Ritter, Joseph K; Gehr, Todd W B; Gulbins, Erich; Li, Pin-Lan.

Afiliação

Li G; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Kidd J; Division of Nephrology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Kaspar C; Division of Nephrology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Dempsey S; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Bhat OM; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Camus S; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Ritter JK; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia.
Gehr TWB; Division of Nephrology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Gulbins E; Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.
Li PL; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia. Electronic address: pin-lan.li@vcuhealth.org.

Am J Pathol ; 190(6): 1211-1223, 2020 06.

Article em En | MEDLINE | ID: mdl-32194052

Assuntos

Ceramidase Ácida/genética; Ceramidas/metabolismo; Glomérulos Renais/metabolismo; Síndrome Nefrótica/metabolismo; Podócitos/metabolismo; Ceramidase Ácida/metabolismo; Animais; Glomérulos Renais/patologia; Glomérulos Renais/ultraestrutura; Camundongos; Camundongos Knockout; Microscopia Eletrônica de Transmissão; Síndrome Nefrótica/genética; Síndrome Nefrótica/patologia; Podócitos/patologia; Podócitos/ultraestrutura

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ceramidas / Podócitos / Ceramidase Ácida / Glomérulos Renais / Síndrome Nefrótica Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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