Your browser doesn't support javascript.
loading
Data set of intrinsically disordered proteins analysed at a local protein conformation level.
Melarkode Vattekatte, Akhila; Narwani, Tarun Jairaj; Floch, Aline; Maljkovic, Mirjana; Bisoo, Soubika; Shinada, Nicolas K; Kranjc, Agata; Gelly, Jean-Christophe; Srinivasan, Narayanaswamy; Mitic, Nenad; de Brevern, Alexandre G.
Afiliação
  • Melarkode Vattekatte A; Biologie Intégrée du Globule Rouge UMR_S1134, Inserm, Univ. Paris, Univ. de la Réunion, Univ. des Antilles, F-75739 Paris, France.
  • Narwani TJ; Laboratoire d'Excellence GR-Ex, F-75739 Paris, France.
  • Floch A; Faculté des Sciences et Technologies, Saint Denis Messag, F-97715 La Réunion, France.
  • Maljkovic M; Institut National de la Transfusion Sanguine (INTS), F-75739 Paris, France.
  • Bisoo S; Biologie Intégrée du Globule Rouge UMR_S1134, Inserm, Univ. Paris, Univ. de la Réunion, Univ. des Antilles, F-75739 Paris, France.
  • Shinada NK; Laboratoire d'Excellence GR-Ex, F-75739 Paris, France.
  • Kranjc A; Institut National de la Transfusion Sanguine (INTS), F-75739 Paris, France.
  • Gelly JC; Laboratoire d'Excellence GR-Ex, F-75739 Paris, France.
  • Srinivasan N; Etablissement Français du Sang Ile de France, Créteil, France.
  • Mitic N; IMRB - INSERM U955 Team 2, Transfusion et maladies du globule rouge, Paris Est- Créteil Univ., Créteil, France.
  • de Brevern AG; UPEC, Université Paris Est-Créteil, Créteil, France.
Data Brief ; 29: 105383, 2020 Apr.
Article em En | MEDLINE | ID: mdl-32195305
Intrinsic Disorder Proteins (IDPs) have become a hot topic since their characterisation in the 90s. The data presented in this article are related to our research entitled "A structural entropy index to analyse local conformations in Intrinsically Disordered Proteins" published in Journal of Structural Biology [1]. In this study, we quantified, for the first time, continuum from rigidity to flexibility and finally disorder. Non-disordered regions were also highlighted in the ensemble of disordered proteins. This work was done using the Protein Ensemble Database (PED), which is a useful database collecting series of protein structures considered as IDPs. The data set consists of a collection of cleaned protein files in classical pdb format that can be readily used as an input with most automatic analysis software. The accompanying data include the coding of all structural information in terms of a structural alphabet, namely Protein Blocks (PBs). An entropy index derived from PBs that allows apprehending the continuum between protein rigidity to flexibility to disorder is included, with information from secondary structure assignment, protein accessibility and prediction of disorder from the sequences. The data may be used for further structural bioinformatics studies of IDPs. It can also be used as a benchmark for evaluating disorder prediction methods.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article