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Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication.
Hulme, Heather; Meikle, Lynsey M; Strittmatter, Nicole; van der Hooft, Justin J J; Swales, John; Bragg, Ryan A; Villar, Victor H; Ormsby, Michael J; Barnes, Stephanie; Brown, Sheila L; Dexter, Alex; Kamat, Maya T; Komen, Jasper C; Walker, Daniel; Milling, Simon; Osterweil, Emily K; MacDonald, Andrew S; Schofield, Chris J; Tardito, Saverio; Bunch, Josephine; Douce, Gillian; Edgar, Julia M; Edrada-Ebel, RuAngelie; Goodwin, Richard J A; Burchmore, Richard; Wall, Daniel M.
Afiliação
  • Hulme H; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Meikle LM; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Strittmatter N; Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • van der Hooft JJJ; Bioinformatics Group, Wageningen University, Wageningen 6708 PB, Netherlands.
  • Swales J; Imaging and data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Bragg RA; Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Villar VH; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
  • Ormsby MJ; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Barnes S; Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, and The Patrick Wild Centre, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
  • Brown SL; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9NT, UK.
  • Dexter A; National Physical Laboratory, Teddington, Middlesex TW11 0LW, UK.
  • Kamat MT; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Komen JC; Oncology Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.
  • Walker D; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Milling S; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Osterweil EK; Centre for Discovery Brain Sciences, Simons Initiative for the Developing Brain, and The Patrick Wild Centre, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK.
  • MacDonald AS; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9NT, UK.
  • Schofield CJ; Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
  • Tardito S; Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
  • Bunch J; Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.
  • Douce G; National Physical Laboratory, Teddington, Middlesex TW11 0LW, UK.
  • Edgar JM; Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington Campus, London SW7 2AZ, UK.
  • Edrada-Ebel R; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Goodwin RJA; Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Burchmore R; Department of Neurogenetics, Max Planck Institute for Experimental Medicine, Hermann-Rein-Strasse 3, D-37075 Goettingen, Germany.
  • Wall DM; Natural Products Metabolomics Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK.
Sci Adv ; 6(11): eaax6328, 2020 03.
Article em En | MEDLINE | ID: mdl-32195337

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina / Substância Branca / Clostridiales / Microbioma Gastrointestinal / Mucosa Intestinal Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina / Substância Branca / Clostridiales / Microbioma Gastrointestinal / Mucosa Intestinal Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article