Your browser doesn't support javascript.
loading
Impact of vascular anomalies on the PTEN phenotype in children and young adults.
Gurunathan, Arun; Ricci, Kiersten; Iacobas, Ionela; Rednam, Surya P; Wusik, Katie; Fei, Lin; Hammilll, Adrienne M.
Afiliação
  • Gurunathan A; Department of Pediatrics, Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, Washington.
  • Ricci K; Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Iacobas I; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Rednam SP; Section of Hematology/Oncology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
  • Wusik K; Section of Hematology/Oncology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
  • Fei L; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Hammilll AM; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Pediatr Blood Cancer ; 67(6): e28258, 2020 06.
Article em En | MEDLINE | ID: mdl-32196895
Germline PTEN (phosphatase and tensin homolog) mutations lead to inappropriate cell survival and growth, and a predisposition to multiple cancers. Some patients also have vascular anomalies (VAs), and it is unclear whether these patients have different phenotypes or oncologic risks. We conducted a two-institution retrospective cohort study to better understand the phenotypes of children and young adults with PTEN mutations, and to compare individuals with VA to those without. Almost half of the patients had thyroid tumors and nearly one quarter developed gastrointestinal tumors before 30 years of age. The presence of VA was positively associated with bulky overgrowth but did not appear to modify oncologic risk.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / PTEN Fosfo-Hidrolase / Malformações Vasculares / Neoplasias Gastrointestinais / Mutação / Neovascularização Patológica Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Glândula Tireoide / PTEN Fosfo-Hidrolase / Malformações Vasculares / Neoplasias Gastrointestinais / Mutação / Neovascularização Patológica Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Ano de publicação: 2020 Tipo de documento: Article