Self-control of vitamin K2 production captured in the crystal.
J Biol Chem
; 295(12): 3771-3772, 2020 03 20.
Article
em En
| MEDLINE
| ID: mdl-32198187
ABSTRACT
Menaquinone (MK) or vitamin K2 is an important metabolite that controls the redox/energy status of Mycobacterium tuberculosis Although the major steps of MK biosynthesis have been delineated, the regulatory mechanisms of this pathway have not been adequately explored. Bashiri et al. now demonstrate that MenD, catalyzing the first committed step of MK production, is allosterically inhibited by a downstream cytosolic metabolite in the MK biosynthesis pathway.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autocontrole
/
Mycobacterium tuberculosis
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article