Protease-activated receptor 2 deficiency in hematopoietic lineage protects against myocardial infarction through attenuated inflammatory response and fibrosis.

Zuo, Pengfei; Zhu, Yinghong; Li, Yongjun; Zuo, Zhi; Sheng, Zulong; Yan, Gaoliang; Ma, Genshan

Zuo, Pengfei; Zhu, Yinghong; Li, Yongjun; Zuo, Zhi; Sheng, Zulong; Yan, Gaoliang; Ma, Genshan.

Afiliação

Zuo P; Department of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210009, China. Electronic address: zuopengfei1207@sina.com.
Zhu Y; Department of Cardiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, 510150, China. Electronic address: zhukaname@yahoo.co.jp.
Li Y; Department of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210009, China. Electronic address: 517527119@qq.com.
Zuo Z; Department of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210009, China. Electronic address: zuozhi1988@sina.com.
Sheng Z; Department of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210009, China. Electronic address: truemoonmoon@sina.com.
Yan G; Department of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210009, China. Electronic address: 461160702@qq.com.
Ma G; Department of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, Jiangsu Province, 210009, China. Electronic address: genshanma@sina.com.

Biochem Biophys Res Commun ; 526(1): 253-260, 2020 05 21.

Article em En | MEDLINE | ID: mdl-32204916

Assuntos

Linhagem da Célula; Células-Tronco Hematopoéticas/patologia; Inflamação/patologia; Infarto do Miocárdio/patologia; Receptor PAR-2/deficiência; Animais; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Fibroblastos/patologia; Fibrose; Interferon beta/farmacologia; Macrófagos/patologia; Camundongos Endogâmicos C57BL; Camundongos Knockout; Isquemia Miocárdica/patologia; Miocárdio/patologia; Receptor PAR-2/metabolismo

Palavras-chave

Cardiac fibrosis; IFN-ß; Macrophage recruitment; Myocardial infarction; Protease-activated receptor 2

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células-Tronco Hematopoéticas / Linhagem da Célula / Receptor PAR-2 / Inflamação / Infarto do Miocárdio Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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