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Associations of sexually transmitted infections and bacterial vaginosis with abnormal cervical cytology: A cross-sectional survey with 9090 community women in China.
Li, Wu; Liu, Lan-Lan; Luo, Zhen-Zhou; Han, Chun-Yan; Wu, Qiu-Hong; Zhang, Li; Tian, Li-Shan; Yuan, Jun; Zhang, Tao; Chen, Zhong-Wei; Yang, Tu-Bao; Feng, Tie-Jian; Zhang, Min; Chen, Xiang-Sheng.
Afiliação
  • Li W; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Liu LL; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Luo ZZ; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Han CY; Shenzhen Nanshan Maternity & Child Healthcare Hospital, Shenzhen, China.
  • Wu QH; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Zhang L; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Tian LS; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Yuan J; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Zhang T; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Chen ZW; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Yang TB; Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.
  • Feng TJ; Shenzhen Center for Chronic Disease Control, Shenzhen, China.
  • Zhang M; Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China.
  • Chen XS; National Center for STD Control, Nanjing, China.
PLoS One ; 15(3): e0230712, 2020.
Article em En | MEDLINE | ID: mdl-32214342
BACKGROUND: Although it is well acknowledged that persistent infection with high-risk human papillomavirus types in genital sites plays a crucial role in the development of squamous cell cervical carcinoma, there is no unanimous consensus on the association between non-HPV sexually transmitted infections and abnormal cervical cytology. METHODS: In the present study, we evaluated cervical cytology status, sexually transmitted infections and bacterial vaginosis status, and collected social-demographic information among recruited participants to explore the association of STIs and bacterial vaginosis with abnormal cervical cytology. RESULTS: 9,090 women's specimens were successfully tested, with a total of 8,733 (96.1%) women had normal cytology and 357 (3.9%) women exhibited abnormal cytology. The prevalence of HPV, Chlamydia trachomatis, Neisseria gonorrhoeae, and bacterial vaginosis was significantly higher in the ≥ASC-US group than the NILM group (P<0.05). Women with Neisseria gonorrhoeae infection (AOR = 5.30, 95% CIs = 1.30-21.51, P = 0.020) or bacterial vaginosis (AOR = 1.94, 95% CIs = 1.08-3.47, P = 0.026) exhibited an increased risk of abnormal cervical cytology after adjusted for carcinogenic HPV-positive status. CONCLUSIONS: Our results demonstrated that Neisseria gonorrhoeae infection in genital sites and/or bacterial vaginosis may independently increase the risk for cervical cytology abnormalities after adjusted for carcinogenic HPV-positive status. Besides, these results improved our understanding of the etiology of abnormal cervical cytology and may be useful for the management of women with ASC-US cytology.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Sexualmente Transmissíveis / Colo do Útero / Características de Residência / Inquéritos e Questionários / Vaginose Bacteriana Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Sexualmente Transmissíveis / Colo do Útero / Características de Residência / Inquéritos e Questionários / Vaginose Bacteriana Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged País/Região como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article