Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kp<sub>uu</sub>) on Prediction of Drug-Drug Interactions.

Sodhi, Jasleen K; Liu, Shuaibing; Benet, Leslie Z

Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kp_uu) on Prediction of Drug-Drug Interactions.

Sodhi, Jasleen K; Liu, Shuaibing; Benet, Leslie Z.

Afiliação

Sodhi JK; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, 533 Parnassus Ave Rm U68, UCSF Box 0912, San Francisco, CA, 94143, United States.
Liu S; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Benet LZ; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California San Francisco, 533 Parnassus Ave Rm U68, UCSF Box 0912, San Francisco, CA, 94143, United States. leslie.benet@ucsf.edu.

Pharm Res ; 37(4): 73, 2020 Mar 25.

Article em En | MEDLINE | ID: mdl-32215750

Assuntos

Cetoconazol/farmacocinética; Midazolam/farmacocinética; Modelos Químicos; Sangue; Interações Medicamentosas; Humanos; Cetoconazol/química; Fígado/efeitos dos fármacos; Midazolam/química

Palavras-chave

Kpuu; drug-drug interactions; liver-to-blood partitioning; well-stirred model

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Midazolam / Cetoconazol / Modelos Químicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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