Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit ofSimplified Structures and Potent ß-<i>N</i>-Acetylhexosaminidase Inhibition.

Yan, Xin; Shimadate, Yuna; Kato, Atsushi; Li, Yi-Xian; Jia, Yue-Mei; Fleet, George W J; Yu, Chu-Yi

Synthesis of Pyrrolidine Monocyclic Analogues of Pochonicine and Its Stereoisomers: Pursuit ofSimplified Structures and Potent ß-N-Acetylhexosaminidase Inhibition.

Yan, Xin; Shimadate, Yuna; Kato, Atsushi; Li, Yi-Xian; Jia, Yue-Mei; Fleet, George W J; Yu, Chu-Yi.

Afiliação

Yan X; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Shimadate Y; University of Chinese Academy of Sciences, Beijing 100049, China.
Kato A; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Li YX; Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Jia YM; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Fleet GWJ; University of Chinese Academy of Sciences, Beijing 100049, China.
Yu CY; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Molecules ; 25(7)2020 Mar 25.

Article em En | MEDLINE | ID: mdl-32218360

Assuntos

Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Pirrolidinas/química; Alcaloides de Pirrolizidina/química; Alcaloides de Pirrolizidina/síntese química; beta-N-Acetil-Hexosaminidases/antagonistas & inibidores; Animais; Ciclização; Glicosídeo Hidrolases/antagonistas & inibidores; Glicosídeo Hidrolases/metabolismo; Ratos; Estereoisomerismo; beta-N-Acetil-Hexosaminidases/metabolismo

Palavras-chave

Pochonicine; iminosugars; pharmacophore; structure-activity relationship; synthesis; ß-N-acetylhexosaminidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirrolidinas / Alcaloides de Pirrolizidina / Beta-N-Acetil-Hexosaminidases / Inibidores Enzimáticos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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