Association of Nijmegen Breakage Syndrome 1 Genotypes With Bladder Cancer Risk.
Anticancer Res
; 40(4): 2011-2017, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-32234891
ABSTRACT
BACKGROUND/AIM:
We aimed to examine the association of the genotypes of Nijmegen breakage syndrome 1 (NBS1), a critical gene in DNA double strand break repair machinery, with bladder cancer risk in Taiwan. MATERIALS ANDMETHODS:
NBS1 rs1805794 genotypes among 375 bladder cancer patients and 375 non-cancer healthy controls were determined via the polymerase chain reaction-restriction fragment length polymorphism methodology and their association with bladder cancer risk were evaluated.RESULTS:
The results showed that the percentages of GG, CG and CC of NBS1 rs1805794 genotypes were 45.4%, 43.7% and 10.9% in the bladder cancer patient group and 47.2%, 43.2% and 9.6% in the non-cancer control group, respectively (p for trend=0.7873). The analysis of allelic frequency distributions showed that the variant C allele of NBS1 rs1805794 does not contribute to an increased bladder cancer susceptibility (p=0.5066).CONCLUSION:
The genotypes of NBS1 rs1805794 are not closely associated with personal susceptibility to bladder cancer.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Proteínas Nucleares
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Proteínas de Ciclo Celular
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Predisposição Genética para Doença
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Estudos de Associação Genética
Tipo de estudo:
Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article