New sesquiterpene glycoside ester with antiprotozoal activity from the flowers of Calendula officinalis L.
Nat Prod Res
; 35(23): 5250-5254, 2021 Dec.
Article
em En
| MEDLINE
| ID: mdl-32237889
ABSTRACT
Continued chromatographic investigation of Calendula officinalis flowers led to the isolation of two sesquiterpenes, including one new, viridiflorol-10-O-ß-quinovopyranoside-2`-O-(3``-methyl-2``-pentenoate) (1), along with a previously reported compound viridiflorol-10-O-ß-fucopyranoside-2`-O-(3``-methyl-2``-pentenoate) (2). The new compound 1 was tested for antiprotozoal activity against Leishmania donovani Amastigote/THP1 and Trypanosoma brucei and it showed IC50 values of 3.57 and 7.84 µg/mL, respectively, while compound 2 exhibited no activity at the highest concentration tested 10 µg/mL.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Leishmania donovani
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Calendula
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Antiprotozoários
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article