Exosome-transmitted lncRNA UFC1 promotes non-small-cell lung cancer progression by EZH2-mediated epigenetic silencing of PTEN expression.

Zang, Xueyan; Gu, Jianmei; Zhang, Jiayin; Shi, Hui; Hou, Sinan; Xu, Xueying; Chen, Yanke; Zhang, Yu; Mao, Fei; Qian, Hui; Zhu, Taofeng; Xu, Wenrong; Zhang, Xu

Zang, Xueyan; Gu, Jianmei; Zhang, Jiayin; Shi, Hui; Hou, Sinan; Xu, Xueying; Chen, Yanke; Zhang, Yu; Mao, Fei; Qian, Hui; Zhu, Taofeng; Xu, Wenrong; Zhang, Xu.

Afiliação

Zang X; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Gu J; Departmemt of Clinical Laboratory Medicine, Nantong Tumor Hospital, 30 Tongyang North Road, 226361, Nantong, Jiangsu, China.
Zhang J; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Shi H; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Hou S; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Xu X; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Chen Y; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Zhang Y; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Mao F; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Qian H; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China.
Zhu T; Department of Respiratory Medicine, the Affiliated Yixing Hospital of Jiangsu University, 75 Tongzhenguan Road, 214200, Yixing, Jiangsu, China. staff1639@qq.com.
Xu W; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China. icls@ujs.edu.cn.
Zhang X; Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, 212013, Zhenjiang, Jiangsu, China. xuzhang@ujs.edu.cn.

Cell Death Dis ; 11(4): 215, 2020 04 02.

Article em En | MEDLINE | ID: mdl-32242003

Assuntos

Carcinoma Pulmonar de Células não Pequenas/genética; Exossomos/genética; Neoplasias Pulmonares/genética; PTEN Fosfo-Hidrolase/biossíntese; Enzimas de Conjugação de Ubiquitina/genética; Células A549; Animais; Carcinoma Pulmonar de Células não Pequenas/metabolismo; Carcinoma Pulmonar de Células não Pequenas/patologia; Estudos de Casos e Controles; Linhagem Celular Tumoral; Movimento Celular/fisiologia; Proliferação de Células/fisiologia; Modelos Animais de Doenças; Progressão da Doença; Proteína Potenciadora do Homólogo 2 de Zeste/genética; Proteína Potenciadora do Homólogo 2 de Zeste/metabolismo; Epigênese Genética; Exossomos/metabolismo; Exossomos/patologia; Xenoenxertos; Humanos; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Invasividade Neoplásica; PTEN Fosfo-Hidrolase/genética; PTEN Fosfo-Hidrolase/metabolismo; RNA Longo não Codificante; Transfecção; Enzimas de Conjugação de Ubiquitina/metabolismo; Regulação para Cima

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Enzimas de Conjugação de Ubiquitina / PTEN Fosfo-Hidrolase / Exossomos / Neoplasias Pulmonares Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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