Endothelial-epithelial communication in polycystic kidney disease: Role of vascular endothelial growth factor signalling.
Cell Signal
; 72: 109624, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32243961
ABSTRACT
Whereas targeting the cyst epithelium and its molecular machinery has been the prevailing clinical strategy for polycystic kidney disease, the endothelium, including blood vasculature and lymphatics, is emerging as an important player in this disorder. In this Review, we provide an overview of the structural and functional alterations to blood vasculature and lymphatic vessels in the polycystic kidney. We also discuss evidence for vascular endothelial growth factor signalling, otherwise critical for endothelial cell development and maintenance, as being a fundamental molecular pathway in polycystic kidney disease and a potential therapeutic target for modulating cyst expansion.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Comunicação Celular
/
Células Endoteliais
/
Fator A de Crescimento do Endotélio Vascular
/
Células Epiteliais
/
Doenças Renais Policísticas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article