MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by &#916;<sup>9</sup>-tetrahydrocannabinol and cannabidiol in human macrophages.

Fitzpatrick, John-Mark; Minogue, Eleanor; Curham, Lucy; Tyrrell, Harry; Gavigan, Philip; Hind, William; Downer, Eric J

MyD88-dependent and -independent signalling via TLR3 and TLR4 are differentially modulated by Δ⁹-tetrahydrocannabinol and cannabidiol in human macrophages.

Fitzpatrick, John-Mark; Minogue, Eleanor; Curham, Lucy; Tyrrell, Harry; Gavigan, Philip; Hind, William; Downer, Eric J.

Afiliação

Fitzpatrick JM; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland.
Minogue E; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland.
Curham L; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland.
Tyrrell H; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland.
Gavigan P; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland.
Hind W; GW Research Ltd, Sovereign House, Vision Park, Histon, CB24 9BZ, United Kingdom.
Downer EJ; Discipline of Physiology, School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Ireland. Electronic address: edowner@tcd.ie.

J Neuroimmunol ; 343: 577217, 2020 06 15.

Article em En | MEDLINE | ID: mdl-32244040

Assuntos

Canabidiol/farmacologia; Dronabinol/farmacologia; Macrófagos/efeitos dos fármacos; Transdução de Sinais/imunologia; Receptor 3 Toll-Like/efeitos dos fármacos; Receptor 4 Toll-Like/efeitos dos fármacos; Linhagem Celular; Humanos; Inflamação/imunologia; Inflamação/metabolismo; Macrófagos/imunologia; Macrófagos/metabolismo; Fator 88 de Diferenciação Mieloide/efeitos dos fármacos; Fator 88 de Diferenciação Mieloide/imunologia; Fator 88 de Diferenciação Mieloide/metabolismo; Transdução de Sinais/efeitos dos fármacos; Receptor 3 Toll-Like/imunologia; Receptor 3 Toll-Like/metabolismo; Receptor 4 Toll-Like/imunologia; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Cannabidiol; IRF; Inflammation; Innate immunity; Macrophages; NF-κB; TLR; Tetrahydrocannabinol

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dronabinol / Canabidiol / Transdução de Sinais / Receptor 3 Toll-Like / Receptor 4 Toll-Like / Macrófagos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google