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Neuromodulation of Brain State and Behavior.
McCormick, David A; Nestvogel, Dennis B; He, Biyu J.
Afiliação
  • McCormick DA; Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA; email: davidmc@uoregon.edu.
  • Nestvogel DB; Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA; email: davidmc@uoregon.edu.
  • He BJ; Departments of Neurology, Neuroscience and Physiology, and Radiology, Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Annu Rev Neurosci ; 43: 391-415, 2020 07 08.
Article em En | MEDLINE | ID: mdl-32250724
Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans and animals reveal that these variations are not random in their nature, but may in fact be due in large part to rapid shifts in neural, cognitive, and behavioral states. Here we review recent advances in the understanding of rapid variations in the waking state, how variations are generated, and how they modulate neural and behavioral responses in both mice and humans. We propose that the brain has an identifiable set of states through which it wanders continuously in a nonrandom fashion, owing to the activity of both ascending modulatory and fast-acting corticocortical and subcortical-cortical neural pathways. These state variations provide the backdrop upon which the brain operates, and understanding them is critical to making progress in revealing the neural mechanisms underlying cognition and behavior.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento / Encéfalo / Rede Nervosa / Vias Neurais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Comportamento / Encéfalo / Rede Nervosa / Vias Neurais Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article