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Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.
Fensome, Andrew; Ambler, Catherine M; Arnold, Eric; Banker, Mary Ellen; Clark, James D; Dowty, Martin E; Efremov, Ivan V; Flick, Andrew; Gerstenberger, Brian S; Gifford, Roger S; Gopalsamy, Ariamala; Hegen, Martin; Jussif, Jason; Limburg, David C; Lin, Tsung H; Pierce, Betsy S; Sharma, Raman; Trujillo, John I; Vajdos, Felix F; Vincent, Fabien; Wan, Zhao-Kui; Xing, Li; Yang, Xiaojing; Yang, Xin.
Afiliação
  • Fensome A; Medicine Design, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States. Electronic address: Andrew.Fensome@Pfizer.Com.
  • Ambler CM; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Arnold E; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Banker ME; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Clark JD; Inflammation and Immunology, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Dowty ME; Medicine Design, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Efremov IV; Medicine Design, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Flick A; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Gerstenberger BS; Medicine Design, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Gifford RS; Inflammation and Immunology, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Gopalsamy A; Medicine Design, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Hegen M; Inflammation and Immunology, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Jussif J; Inflammation and Immunology, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Limburg DC; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Lin TH; Inflammation and Immunology, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Pierce BS; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Sharma R; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Trujillo JI; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Vajdos FF; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Vincent F; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
  • Wan ZK; Medicine Design, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Xing L; Medicine Design, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Yang X; Medicine Design, Pfizer Inc, 1 Portland Street, Cambridge, MA 02139, United States.
  • Yang X; Medicine Design, Pfizer Inc, Eastern Point Road, Groton, CT 06340, United States.
Bioorg Med Chem ; 28(10): 115481, 2020 05 15.
Article em En | MEDLINE | ID: mdl-32253095
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Desenho de Fármacos / Inibidores de Proteínas Quinases / Janus Quinase 1 / TYK2 Quinase Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Desenho de Fármacos / Inibidores de Proteínas Quinases / Janus Quinase 1 / TYK2 Quinase Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article