Localized Immunomodulation with PD-L1 Results in Sustained Survival and Function of Allogeneic Islets without Chronic Immunosuppression.

Batra, Lalit; Shrestha, Pradeep; Zhao, Hong; Woodward, Kyle B; Togay, Alper; Tan, Min; Grimany-Nuno, Orlando; Malik, Mohammad Tariq; Coronel, María M; García, Andrés J; Shirwan, Haval; Yolcu, Esma S

Batra, Lalit; Shrestha, Pradeep; Zhao, Hong; Woodward, Kyle B; Togay, Alper; Tan, Min; Grimany-Nuno, Orlando; Malik, Mohammad Tariq; Coronel, María M; García, Andrés J; Shirwan, Haval; Yolcu, Esma S.

Afiliação

Batra L; Institute for Cellular Therapeutics, School of Medicine, University of Louisville, Louisville, KY 40202.
Shrestha P; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40202.
Zhao H; Institute for Cellular Therapeutics, School of Medicine, University of Louisville, Louisville, KY 40202.
Woodward KB; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40202.
Togay A; Institute for Cellular Therapeutics, School of Medicine, University of Louisville, Louisville, KY 40202.
Tan M; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40202.
Grimany-Nuno O; Institute for Cellular Therapeutics, School of Medicine, University of Louisville, Louisville, KY 40202.
Malik MT; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40202.
Coronel MM; Institute for Cellular Therapeutics, School of Medicine, University of Louisville, Louisville, KY 40202.
García AJ; Institute for Cellular Therapeutics, School of Medicine, University of Louisville, Louisville, KY 40202.
Shirwan H; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY 40202.
Yolcu ES; Institute for Cellular Therapeutics, School of Medicine, University of Louisville, Louisville, KY 40202.

J Immunol ; 204(10): 2840-2851, 2020 05 15.

Article em En | MEDLINE | ID: mdl-32253240

Assuntos

Aloenxertos/fisiologia; Antígeno B7-H1/metabolismo; Diabetes Mellitus Tipo 1/imunologia; Terapia de Imunossupressão/métodos; Ilhotas Pancreáticas/fisiologia; Estreptavidina/metabolismo; Linfócitos T Reguladores/imunologia; Animais; Antígeno B7-H1/genética; Diferenciação Celular; Sobrevivência Celular; Fatores de Transcrição Forkhead/metabolismo; Humanos; Tolerância Imunológica; Imunidade/genética; Imunomodulação; Transplante das Ilhotas Pancreáticas; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C3H; Camundongos Endogâmicos C57BL; Proteínas Recombinantes de Fusão/genética; Estreptavidina/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ilhotas Pancreáticas / Terapia de Imunossupressão / Linfócitos T Reguladores / Estreptavidina / Diabetes Mellitus Tipo 1 / Antígeno B7-H1 / Aloenxertos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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