A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine <i>Penicillium antarcticum</i> as Inhibitors of Mesenchymal Stem Cell Differentiation.

Marchese, Pietro; Mahajan, Nipun; O'Connell, Enda; Fearnhead, Howard; Tuohy, Maria; Krawczyk, Janusz; Thomas, Olivier P; Barry, Frank; Murphy, Mary J

A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation.

Marchese, Pietro; Mahajan, Nipun; O'Connell, Enda; Fearnhead, Howard; Tuohy, Maria; Krawczyk, Janusz; Thomas, Olivier P; Barry, Frank; Murphy, Mary J.

Afiliação

Marchese P; Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland.
Mahajan N; Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, H91TK33 Galway, Ireland.
O'Connell E; Genomics and Screening Core, National Centre for Biomedical Engineering Science, National University of Ireland Galway, H91TK33 Galway, Ireland.
Fearnhead H; Pharmacology and Therapeutics, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland.
Tuohy M; Molecular Glycobiotechnology, School of Natural Sciences, National University of Ireland Galway, H91TK33 Galway, Ireland.
Krawczyk J; Galway University Hospital, National University of Ireland Galway, School of Medicine, H91YR71 Galway, Ireland.
Thomas OP; Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, H91TK33 Galway, Ireland.
Barry F; Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland.
Murphy MJ; Regenerative Medicine Institute, School of Medicine, National University of Ireland Galway, H91TK33 Galway, Ireland.

Mar Drugs ; 18(4)2020 Apr 05.

Article em En | MEDLINE | ID: mdl-32260516

Assuntos

Diferenciação Celular/efeitos dos fármacos; Ensaios de Triagem em Larga Escala/métodos; Penicillium/química; Bibliotecas de Moléculas Pequenas/farmacologia; Succinatos/química; Succinatos/farmacologia; Células Cultivadas; Condrogênese/efeitos dos fármacos; Condrogênese/fisiologia; Descoberta de Drogas/métodos; Humanos; Células-Tronco Mesenquimais/efeitos dos fármacos; Osteogênese/efeitos dos fármacos; Osteogênese/fisiologia; Medicina Regenerativa

Palavras-chave

Penicillium antarcticum; drug discovery; high throughput screening; marine fungi; regenerative medicine; stem cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium / Succinatos / Diferenciação Celular / Bibliotecas de Moléculas Pequenas / Ensaios de Triagem em Larga Escala Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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