Your browser doesn't support javascript.
loading
Ovarian metastases from ileum cancer in a patient with germline EPCAM gene deletion successfully treated with surgical resection and CAPOX chemotherapy: a case report.
Iwata, Narushi; Shikama, Ayumi; Takao, Wataru; Hosokawa, Yoshihiko; Itagaki, Hiroya; Tasaka, Nobutaka; Akiyama, Azusa; Ochi, Hiroyuki; Minaguchi, Takeo; Arita, Miwa; Noguchi, Emiko; Moriwaki, Toshikazu; Satoh, Toyomi.
Afiliação
  • Iwata N; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Shikama A; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan. ashikama@md.tsukuba.ac.jp.
  • Takao W; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Hosokawa Y; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Itagaki H; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Tasaka N; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Akiyama A; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Ochi H; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Minaguchi T; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
  • Arita M; Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Noguchi E; Department of Medical Genetics, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Moriwaki T; Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Satoh T; Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
BMC Med Genet ; 21(1): 76, 2020 04 09.
Article em En | MEDLINE | ID: mdl-32272879
ABSTRACT

BACKGROUND:

Despite recent findings that epithelial cell adhesion molecule (EPCAM) deletions can cause Lynch syndrome (LS), its clinical characteristics are still unknown. We present the first case of ileum cancer in a patient with germline EPCAM gene deletion, which was discovered during ovarian tumor surgery. CASE PRESENTATION A 59-year-old woman presented with a history of colon cancer occurring at 38 and 55 years old. Five of her siblings had a history of colon cancer, and an elder sister had confirmed LS. As imaging examination revealed an ovarian tumor, and we performed hysterectomy and bilateral salpingo-oophorectomy. Careful observation during surgery revealed a cherry-sized tumor in the ileum, prompting partial ileal resection. Pathological examination showed the ovarian tumor to be a metastasis of ileum cancer. Genetic testing with blood-relative information using multiplex ligation-dependent probe amplification showed EPCAM exons 8 and 9 deletions, confirming LS. The patient received adjuvant chemotherapy with CAPOX (capecitabine and oxaliplatin) and has remained disease-free for 24 months.

CONCLUSIONS:

We were fortunate to identify ileum cancer that would have been difficult to find preoperatively through careful observation during ovarian tumor surgery and successfully treated the patient by using surgical resection and CAPOX chemotherapy. When treating patients with hereditary cancer syndromes including LS, we should keep all associated cancers in mind.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Ovariectomia / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Molécula de Adesão da Célula Epitelial / Neoplasias do Íleo Tipo de estudo: Prognostic_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Ovariectomia / Adenocarcinoma / Protocolos de Quimioterapia Combinada Antineoplásica / Molécula de Adesão da Célula Epitelial / Neoplasias do Íleo Tipo de estudo: Prognostic_studies Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article