Long noncoding RNA lnc-RI regulates DNA damage repair and radiation sensitivity of CRC cells through NHEJ pathway.

Liu, Ruixue; Zhang, Qingtong; Shen, Liping; Chen, Shuangjing; He, Junyan; Wang, Dong; Wang, Qi; Qi, Zhenhua; Zhou, Meijuan; Wang, Zhidong

Liu, Ruixue; Zhang, Qingtong; Shen, Liping; Chen, Shuangjing; He, Junyan; Wang, Dong; Wang, Qi; Qi, Zhenhua; Zhou, Meijuan; Wang, Zhidong.

Afiliação

Liu R; Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Zhang Q; Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, People's Republic of China.
Shen L; Department of Colorectal Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, People's Republic of China.
Chen S; Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
He J; PLA Rocket Force Characteristic Medical Center, Beijing, People's Republic of China.
Wang D; Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Wang Q; Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Qi Z; Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Zhou M; Department of Radiobiology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, People's Republic of China.
Wang Z; Department of Radiation Medicine, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, People's Republic of China.

Cell Biol Toxicol ; 36(5): 493-507, 2020 10.

Article em En | MEDLINE | ID: mdl-32279126

Assuntos

Neoplasias Colorretais/genética; Dano ao DNA/genética; Reparo do DNA por Junção de Extremidades/genética; RNA Longo não Codificante/metabolismo; Tolerância a Radiação/genética; Adulto; Idoso; Idoso de 80 Anos ou mais; Animais; Sequência de Bases; Ligação Competitiva; Pontos de Checagem do Ciclo Celular/genética; Linhagem Celular Tumoral; Proliferação de Células/genética; Sobrevivência Celular/genética; Neoplasias Colorretais/patologia; Quebras de DNA de Cadeia Dupla; DNA Ligase Dependente de ATP/genética; DNA Ligase Dependente de ATP/metabolismo; Estabilidade Enzimática/genética; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Masculino; Camundongos Nus; Pessoa de Meia-Idade; Modelos Biológicos; RNA Longo não Codificante/genética; Transdução de Sinais/genética

Palavras-chave

LIG4; Lnc-RI; Non-homologous end-joining (NHEJ); lncRNA; miR-4727-5p

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tolerância a Radiação / Dano ao DNA / Neoplasias Colorretais / Reparo do DNA por Junção de Extremidades / RNA Longo não Codificante Tipo de estudo: Diagnostic_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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