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A novel class of selective CK2 inhibitors targeting its open hinge conformation.
Dalle Vedove, Andrea; Zonta, Francesca; Zanforlin, Enrico; Demitri, Nicola; Ribaudo, Giovanni; Cazzanelli, Giulia; Ongaro, Alberto; Sarno, Stefania; Zagotto, Giuseppe; Battistutta, Roberto; Ruzzene, Maria; Lolli, Graziano.
Afiliação
  • Dalle Vedove A; Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Via Sommarive 9, 38123, Trento, Italy.
  • Zonta F; Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padua, Via U. Bassi 58/B, 35131, Padua, Italy.
  • Zanforlin E; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Via F. Marzolo 5, 35131, Padua, Italy.
  • Demitri N; Elettra-Sincrotrone Trieste, S.S. 14 Km 163.5 in Area Science Park, 34149, Basovizza-Trieste, Italy.
  • Ribaudo G; Department of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
  • Cazzanelli G; Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Via Sommarive 9, 38123, Trento, Italy.
  • Ongaro A; Department of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Viale Europa 11, 25123, Brescia, Italy.
  • Sarno S; Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padua, Via U. Bassi 58/B, 35131, Padua, Italy.
  • Zagotto G; Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Via F. Marzolo 5, 35131, Padua, Italy. Electronic address: giuseppe.zagotto@unipd.it.
  • Battistutta R; Department of Chemical Sciences and CNR Institute of Biomolecular Chemistry, University of Padua, Via F. Marzolo 1, 35131, Padua, Italy. Electronic address: roberto.battistutta@unipd.it.
  • Ruzzene M; Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padua, Via U. Bassi 58/B, 35131, Padua, Italy. Electronic address: maria.ruzzene@unipd.it.
  • Lolli G; Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Via Sommarive 9, 38123, Trento, Italy. Electronic address: graziano.lolli@unitn.it.
Eur J Med Chem ; 195: 112267, 2020 Jun 01.
Article em En | MEDLINE | ID: mdl-32283296
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Caseína Quinase II / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Caseína Quinase II / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article