Symmetrically substituted dichlorophenes inhibit <i>N</i>-acyl-phosphatidylethanolamine phospholipase D.

Aggarwal, Geetika; Zarrow, Jonah E; Mashhadi, Zahra; Flynn, C Robb; Vinson, Paige; Weaver, C David; Davies, Sean S

Symmetrically substituted dichlorophenes inhibit N-acyl-phosphatidylethanolamine phospholipase D.

Aggarwal, Geetika; Zarrow, Jonah E; Mashhadi, Zahra; Flynn, C Robb; Vinson, Paige; Weaver, C David; Davies, Sean S.

Afiliação

Aggarwal G; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Zarrow JE; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Mashhadi Z; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232.
Flynn CR; Division of Surgery, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
Vinson P; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, Tennessee 37232.
Weaver CD; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232.
Davies SS; Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232; Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37232; Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232. Ele

J Biol Chem ; 295(21): 7289-7300, 2020 05 22.

Article em En | MEDLINE | ID: mdl-32284327

Assuntos

Diclorofeno; Inibidores Enzimáticos; Fosfolipase D; Animais; Proteínas de Bactérias/antagonistas & inibidores; Proteínas de Bactérias/química; Proteínas de Bactérias/metabolismo; Bitionol/química; Bitionol/farmacologia; Diclorofeno/química; Diclorofeno/farmacologia; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Células HEK293; Hexaclorofeno/química; Hexaclorofeno/farmacologia; Humanos; Camundongos; Fosfolipase D/antagonistas & inibidores; Fosfolipase D/química; Fosfolipase D/metabolismo; Quinazolinas/química; Quinazolinas/farmacologia; Streptomyces/enzimologia; Sulfonamidas/química; Sulfonamidas/farmacologia

Palavras-chave

N-acyl-ethanolamide; N-acyl-phosphatidylethanolamine; NAPE-PLD; TGR5; bile acid; dichlorophene; endocannabinoid; high-throughput screening (HTS); lipid signaling; metabolic disease; phospholipase D; proteinlipid interaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfolipase D / Diclorofeno / Inibidores Enzimáticos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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