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Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation.
Ravasio, Roberto; Ceccacci, Elena; Nicosia, Luciano; Hosseini, Amir; Rossi, Pier Luigi; Barozzi, Iros; Fornasari, Lorenzo; Zuffo, Roberto Dal; Valente, Sergio; Fioravanti, Rossella; Mercurio, Ciro; Varasi, Mario; Mattevi, Andrea; Mai, Antonello; Pavesi, Giulio; Bonaldi, Tiziana; Minucci, Saverio.
Afiliação
  • Ravasio R; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.
  • Ceccacci E; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.
  • Nicosia L; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.
  • Hosseini A; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.
  • Rossi PL; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.
  • Barozzi I; Department of Surgery and Cancer, Imperial College London, Hammersmith, London W12, UK.
  • Fornasari L; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.
  • Zuffo RD; EryDel SpA, Via Meucci 3, 20091 Bresso (MI), Italy.
  • Valente S; Experimental Therapeutics Program, FIRC Institute of Molecular Oncology Foundation (IFOM), Via Adamello 16, Milan 20139, Italy.
  • Fioravanti R; Department of Drug Chemistry and Technologies, Pasteur Institute Italy, Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
  • Mercurio C; Department of Drug Chemistry and Technologies, Pasteur Institute Italy, Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
  • Varasi M; Experimental Therapeutics Program, FIRC Institute of Molecular Oncology Foundation (IFOM), Via Adamello 16, Milan 20139, Italy.
  • Mattevi A; Experimental Therapeutics Program, FIRC Institute of Molecular Oncology Foundation (IFOM), Via Adamello 16, Milan 20139, Italy.
  • Mai A; Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy.
  • Pavesi G; Department of Drug Chemistry and Technologies, Pasteur Institute Italy, Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy.
  • Bonaldi T; Department of Biosciences, University of Milan, Milan 20133, Italy.
  • Minucci S; Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Via Adamello 16, Milan 20139, Italy.
Sci Adv ; 6(15): eaax2746, 2020 04.
Article em En | MEDLINE | ID: mdl-32284990
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tretinoína / Leucemia Mieloide Aguda / Diferenciação Celular / Resistencia a Medicamentos Antineoplásicos / Histona Desmetilases / Antineoplásicos Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tretinoína / Leucemia Mieloide Aguda / Diferenciação Celular / Resistencia a Medicamentos Antineoplásicos / Histona Desmetilases / Antineoplásicos Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article