Pitfalls in the analysis of phytocannabinoids in cannabis inflorescence.
Anal Bioanal Chem
; 412(17): 4009-4022, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-32285185
ABSTRACT
The chemical analysis of cannabis potency involves the qualitative and quantitative determination of the main phytocannabinoids Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), cannabigerol (CBG), cannabichromene (CBC), etc. Although it might appear as a trivial analysis, it is rather a tricky task. Phytocannabinoids are present mostly as carboxylated species at the aromatic ring of the resorcinyl moiety. Their decarboxylation caused by heat leads to a greater analytical variability due to both reaction kinetics and possible decomposition. Moreover, the instability of cannabinoids and the variability in the sample preparation, extraction, and analysis, as well as the presence of isomeric forms of cannabinoids, complicates the scenario. A critical evaluation of the different analytical methods proposed in the literature points out that each of them has inherent limitations. The present review outlines all the possible pitfalls that can be encountered during the analysis of these compounds and aims to be a valuable help for the analytical chemist. Graphical abstract.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canabinoides
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Cannabis
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Extratos Vegetais
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Técnicas de Química Analítica
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Inflorescência
Tipo de estudo:
Qualitative_research
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article