Asymmetric Total Synthesis of (-)-Spirochensilide A.
J Am Chem Soc
; 142(18): 8116-8121, 2020 05 06.
Article
em En
| MEDLINE
| ID: mdl-32286815
ABSTRACT
An asymmetric total synthesis of (-)-spirochensilide A has been achieved for the first time. The synthesis features a semipinacol rearrangement reaction to stereoselectively construct the two-vicinal quaternary chiral centers at C8 and C10, a tungsten-mediated cyclopropene-based Pauson-Khand reaction to install the C13 quaternary chiral center, and a furan-based oxidative cyclization to stereoselectively form the spiroketal motif.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article