Antagonism between substitutions in ß-lactamase explains a path not taken in the evolution of bacterial drug resistance.

Brown, Cameron A; Hu, Liya; Sun, Zhizeng; Patel, Meha P; Singh, Sukrit; Porter, Justin R; Sankaran, Banumathi; Prasad, B V Venkataram; Bowman, Gregory R; Palzkill, Timothy

Brown, Cameron A; Hu, Liya; Sun, Zhizeng; Patel, Meha P; Singh, Sukrit; Porter, Justin R; Sankaran, Banumathi; Prasad, B V Venkataram; Bowman, Gregory R; Palzkill, Timothy.

Afiliação

Brown CA; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030.
Hu L; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030.
Sun Z; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030.
Patel MP; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030.
Singh S; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110.
Porter JR; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110.
Sankaran B; Department of Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720.
Prasad BVV; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030.
Bowman GR; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110.
Palzkill T; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas 77030; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030. Electronic address: timothyp@bcm.edu.

J Biol Chem ; 295(21): 7376-7390, 2020 05 22.

Article em En | MEDLINE | ID: mdl-32299911

Assuntos

Proteínas de Escherichia coli/química; Escherichia coli/enzimologia; Evolução Molecular; Mutação de Sentido Incorreto; Resistência beta-Lactâmica; beta-Lactamases/química; Substituição de Aminoácidos; Catálise; Ceftazidima/química; Escherichia coli/genética; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; beta-Lactamases/genética; beta-Lactamases/metabolismo

Palavras-chave

antibiotic resistance; beta-lactam antibiotic; beta-lactamase; cephalosporin; conformational change; enzyme kinetics; enzyme mutation; enzyme structure; protein conformation; protein crystallization; protein drug interaction; protein stability; protein structure

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Beta-Lactamases / Resistência beta-Lactâmica / Evolução Molecular / Mutação de Sentido Incorreto / Proteínas de Escherichia coli / Escherichia coli Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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