Heme protects intestinal mucosal barrier in DSS-induced colitis through regulating macrophage polarization in both HO-1-dependent and HO-1-independent way.

Wu, Yanwei; Wu, Bing; Zhang, Zongwang; Lu, Huimin; Fan, Chen; Qi, Qing; Gao, Yuanzhuo; Li, Heng; Feng, Chunlan; Zuo, Jianping; Tang, Wei

Wu, Yanwei; Wu, Bing; Zhang, Zongwang; Lu, Huimin; Fan, Chen; Qi, Qing; Gao, Yuanzhuo; Li, Heng; Feng, Chunlan; Zuo, Jianping; Tang, Wei.

Afiliação

Wu Y; Laboratory of Anti-inflammation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Wu B; Laboratory of Anti-inflammation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Zhang Z; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China.
Lu H; School of Life Sciences, Shanghai University, Shanghai, China.
Fan C; Laboratory of Anti-inflammation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Qi Q; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China.
Gao Y; Laboratory of Anti-inflammation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Li H; Laboratory of Anti-inflammation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Feng C; Laboratory of Anti-inflammation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Zuo J; School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China.
Tang W; Laboratory of Anti-inflammation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

FASEB J ; 34(6): 8028-8043, 2020 06.

Article em En | MEDLINE | ID: mdl-32301543

Assuntos

Colite/metabolismo; Heme Oxigenase-1/metabolismo; Heme/metabolismo; Mediadores da Inflamação/metabolismo; Mucosa Intestinal/metabolismo; Macrófagos/metabolismo; Proteínas de Membrana/metabolismo; Animais; Anti-Inflamatórios/metabolismo; Colite/induzido quimicamente; Colo/metabolismo; Citocinas/metabolismo; Sulfato de Dextrana/farmacologia; Feminino; Inflamação/metabolismo; Doenças Inflamatórias Intestinais/metabolismo; Fatores Reguladores de Interferon/metabolismo; Mucosa Intestinal/efeitos dos fármacos; Ativação de Macrófagos/fisiologia; Camundongos; Camundongos Endogâmicos C57BL; Fator de Transcrição RelA/metabolismo

Palavras-chave

IBD; M1; M2; ulcerative colitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite / Mediadores da Inflamação / Heme Oxigenase-1 / Heme / Mucosa Intestinal / Macrófagos / Proteínas de Membrana Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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