Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution.
Trends Biochem Sci
; 45(7): 619-632, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32305250
ABSTRACT
N-myristoylation (MYR) is a crucial fatty acylation catalyzed by N-myristoyltransferases (NMTs) that is likely to have appeared over 2 billion years ago. Proteome-wide approaches have now delivered an exhaustive list of substrates undergoing MYR across approximately 2% of any proteome, with constituents, several unexpected, associated with different membrane compartments. A set of <10 proteins conserved in eukaryotes probably represents the original set of N-myristoylated targets, marking major changes occurring throughout eukaryogenesis. Recent findings have revealed unexpected mechanisms and reactivity, suggesting competition with other acylations that are likely to influence cellular homeostasis and the steady state of the modification landscape. Here, we review recent advances in NMT catalysis, substrate specificity, and MYR proteomics, and discuss concepts regarding MYR during evolution.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Mirístico
/
Evolução Biológica
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article