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Heterogeneity in Brain Microstructural Development Following Preterm Birth.
Dimitrova, Ralica; Pietsch, Maximilian; Christiaens, Daan; Ciarrusta, Judit; Wolfers, Thomas; Batalle, Dafnis; Hughes, Emer; Hutter, Jana; Cordero-Grande, Lucilio; Price, Anthony N; Chew, Andrew; Falconer, Shona; Vecchiato, Katy; Steinweg, Johannes K; Carney, Olivia; Rutherford, Mary A; Tournier, J-Donald; Counsell, Serena J; Marquand, Andre F; Rueckert, Daniel; Hajnal, Joseph V; McAlonan, Grainne; Edwards, A David; O'Muircheartaigh, Jonathan.
Afiliação
  • Dimitrova R; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Pietsch M; Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
  • Christiaens D; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Ciarrusta J; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Wolfers T; Department of Electrical Engineering, ESAT/PSI, KU Leuven, Leuven, 3001, Belgium.
  • Batalle D; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Hughes E; Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
  • Hutter J; Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radbound University, Nijmegen, 6525EN, the Netherlands.
  • Cordero-Grande L; Department of Cognitive Neuroscience, Radbound University Medical Centre, Nijmegen, 6525EN, the Netherlands.
  • Price AN; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Chew A; Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
  • Falconer S; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Vecchiato K; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Steinweg JK; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Carney O; Biomedical Image Technologies, ETSI Telecomunicacion, Universidad Politecnica de Madrid and CIBER-BBN, Madrid, 28040, Spain.
  • Rutherford MA; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Tournier JD; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Counsell SJ; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Marquand AF; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Rueckert D; Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 8AF, UK.
  • Hajnal JV; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • McAlonan G; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • Edwards AD; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
  • O'Muircheartaigh J; Centre for the Developing Brain, Department of Perinatal Imaging and Health, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Cereb Cortex ; 30(9): 4800-4810, 2020 07 30.
Article em En | MEDLINE | ID: mdl-32306044
ABSTRACT
Preterm-born children are at increased risk of lifelong neurodevelopmental difficulties. Group-wise analyses of magnetic resonance imaging show many differences between preterm- and term-born infants but do not reliably predict neurocognitive prognosis for individual infants. This might be due to the unrecognized heterogeneity of cerebral injury within the preterm group. This study aimed to determine whether atypical brain microstructural development following preterm birth is significantly variable between infants. Using Gaussian process regression, a technique that allows a single-individual inference, we characterized typical variation of brain microstructure using maps of fractional anisotropy and mean diffusivity in a sample of 270 term-born neonates. Then, we compared 82 preterm infants to these normative values to identify brain regions with atypical microstructure and relate observed deviations to degree of prematurity and neurocognition at 18 months. Preterm infants showed strikingly heterogeneous deviations from typical development, with little spatial overlap between infants. Greater and more extensive deviations, captured by a whole brain atypicality index, were associated with more extreme prematurity and predicted poorer cognitive and language abilities at 18 months. Brain microstructural development after preterm birth is highly variable between individual infants. This poorly understood heterogeneity likely relates to both the etiology and prognosis of brain injury.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Recém-Nascido Prematuro / Nascimento Prematuro Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Recém-Nascido Prematuro / Nascimento Prematuro Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Ano de publicação: 2020 Tipo de documento: Article