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Cannabis sativa L. Inflorescences from Monoecious Cultivars Grown in Central Italy: An Untargeted Chemical Characterization from Early Flowering to Ripening.
Ingallina, Cinzia; Sobolev, Anatoly P; Circi, Simone; Spano, Mattia; Fraschetti, Caterina; Filippi, Antonello; Di Sotto, Antonella; Di Giacomo, Silvia; Mazzoccanti, Giulia; Gasparrini, Francesco; Quaglio, Deborah; Campiglia, Enio; Carradori, Simone; Locatelli, Marcello; Vinci, Giuliana; Rapa, Mattia; Ciano, Salvatore; Giusti, Anna Maria; Botta, Bruno; Ghirga, Francesca; Capitani, Donatella; Mannina, Luisa.
Afiliação
  • Ingallina C; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Sobolev AP; Institute for Biological Systems, Magnetic Resonance Laboratory "Segre-Capitani", CNR, Via Salaria Km 29.300, 00015 Monterotondo, Italy.
  • Circi S; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Spano M; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Fraschetti C; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Filippi A; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Di Sotto A; Department of Physiology and Pharmacology "V. Ersparmer", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
  • Di Giacomo S; Department of Physiology and Pharmacology "V. Ersparmer", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
  • Mazzoccanti G; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Gasparrini F; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Quaglio D; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Campiglia E; Department of Agriculture and Forest Sciences, University of Tuscia, Via San Camillo de Lellis snc, 01100 Viterbo, Italy.
  • Carradori S; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
  • Locatelli M; Department of Pharmacy, University "G. d'Annunzio" of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
  • Vinci G; Department of Management, Sapienza University of Rome, via del Castro Laurenziano 9, 00161 Rome, Italy.
  • Rapa M; Department of Management, Sapienza University of Rome, via del Castro Laurenziano 9, 00161 Rome, Italy.
  • Ciano S; Department of Management, Sapienza University of Rome, via del Castro Laurenziano 9, 00161 Rome, Italy.
  • Giusti AM; Department of Experimental Medicine, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.
  • Botta B; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Ghirga F; Center for Life Nano Science@Sapienza, Italian Institute of Technology, Viale Regina Elena 291, 00161 Rome, Italy.
  • Capitani D; Institute for Biological Systems, Magnetic Resonance Laboratory "Segre-Capitani", CNR, Via Salaria Km 29.300, 00015 Monterotondo, Italy.
  • Mannina L; Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Molecules ; 25(8)2020 Apr 20.
Article em En | MEDLINE | ID: mdl-32326129
ABSTRACT
The chemical composition of the inflorescences from four Cannabis sativa L. monoecious cultivars (Ferimon, Uso-31, Felina 32 and Fedora 17), recently introduced in the Lazio Region, was monitored over the season from June to September giving indications on their sensorial, pharmaceutical/nutraceutical proprieties. Both untargeted (NMR) and targeted (GC/MS, UHPLC, HPLC-PDA/FD and spectrophotometry) analyses were carried out to identify and quantify compounds of different classes (sugars, organic acids, amino acids, cannabinoids, terpenoids, phenols, tannins, flavonoids and biogenic amines). All cultivars in each harvesting period showed a THC content below the Italian legal limit, although in general THC content increased over the season. Citric acid, malic acid and glucose showed the highest content in the late flowering period, whereas the content of proline drastically decreased after June in all cultivars. Neophytadiene, nerolidol and chlorogenic acid were quantified only in Felina 32 cultivar, characterized also by a very high content of flavonoids, whereas alloaromadendrene and trans-cinnamic acid were detected only in Uso-31 cultivar. Naringenin and naringin were present only in Fedora 17 and Ferimon cultivars, respectively. Moreover, Ferimon had the highest concentration of biogenic amines, especially in July and August. Cadaverine was present in all cultivars but only in September. These results suggest that the chemical composition of Cannabis sativa L. inflorescences depends on the cultivar and on the harvesting period. Producers can use this information as a guide to obtain inflorescences with peculiar chemical characteristics according to the specific use.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cannabis / Inflorescência Tipo de estudo: Prognostic_studies País/Região como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cannabis / Inflorescência Tipo de estudo: Prognostic_studies País/Região como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article