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Characterization of Cas12a nucleases reveals diverse PAM profiles between closely-related orthologs.
Jacobsen, Thomas; Ttofali, Fani; Liao, Chunyu; Manchalu, Srinivas; Gray, Benjamin N; Beisel, Chase L.
Afiliação
  • Jacobsen T; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.
  • Ttofali F; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.
  • Liao C; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), 97080 Würzburg, Germany.
  • Manchalu S; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Centre for Infection Research (HZI), 97080 Würzburg, Germany.
  • Gray BN; Benson Hill, St. Louis, MO, 63132, USA.
  • Beisel CL; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.
Nucleic Acids Res ; 48(10): 5624-5638, 2020 06 04.
Article em En | MEDLINE | ID: mdl-32329776
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Endodesoxirribonucleases / Proteínas Associadas a CRISPR Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Endodesoxirribonucleases / Proteínas Associadas a CRISPR Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article