Clozapine-Related Diarrhea and Colitis: Report of 4 Cases.
J Clin Psychopharmacol
; 40(3): 293-296, 2020.
Article
em En
| MEDLINE
| ID: mdl-32332465
ABSTRACT
BACKGROUND:
During clozapine treatment, diarrhea is a rare but clinically relevant adverse effect. Cases of microscopic colitis and eosinophilic colitis have been previously reported. PROCEDURES We present 4 patients who developed severe diarrhea in early weeks of clozapine therapy.FINDINGS:
Two patients had significant peripheral eosinophilia 1 week after diarrhea symptoms. One of these patients also had Charcot-Leyden crystals in stool afterward, confirming the presence of eosinophils in the gut lumen. One of our patients had a confirmed microscopic colitis and later also neutropenia, which required treatment.CONCLUSIONS:
Charcot-Leyden crystals in stool may be associated with concurrent diarrhea and eosinophilia during clozapine treatment, which is a previously unreported finding. Occurrence of blood dyscrasias with diarrhea symptoms during clozapine treatment needs further investigation to understand the possible shared mechanisms.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clozapina
/
Colite
/
Colite Microscópica
/
Diarreia
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article