SUMOylation modulates the LIN28A-let-7 signaling pathway in response to cellular stresses in cancer cells.

Dou, Jinzhuo; Zhang, Hailong; Chen, Ran; Shu, Zimei; Yuan, Haihua; Zhao, Xian; Wang, Yanli; Huang, Jian; Zhou, Aiwu; Yu, Jianxiu

Dou, Jinzhuo; Zhang, Hailong; Chen, Ran; Shu, Zimei; Yuan, Haihua; Zhao, Xian; Wang, Yanli; Huang, Jian; Zhou, Aiwu; Yu, Jianxiu.

Afiliação

Dou J; Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang H; Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen R; Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shu Z; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuan H; Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhao X; Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wang Y; Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huang J; Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhou A; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu J; Department of Biochemistry and Molecular Cell Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Mol Oncol ; 14(9): 2288-2312, 2020 09.

Article em En | MEDLINE | ID: mdl-32333719

Assuntos

MicroRNAs/metabolismo; Transdução de Sinais; Estresse Fisiológico; Sumoilação; Animais; Carcinogênese/genética; Hipóxia Celular/genética; Linhagem Celular Tumoral; Proliferação de Células/genética; Regulação Neoplásica da Expressão Gênica; Humanos; Lisina/genética; Lisina/metabolismo; Camundongos Nus; MicroRNAs/genética; Mutação/genética; Neoplasias/tratamento farmacológico; Neoplasias/genética; Neoplasias/patologia; Ligação Proteica; Proteínas de Ligação a RNA/genética; Proteínas de Ligação a RNA/metabolismo; Estresse Fisiológico/genética; Uridina/metabolismo

Palavras-chave

LIN28A; SUMOylation; binding affinity to precursor let-7; cancer progression; let-7 biogenesis; stresses

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Fisiológico / Transdução de Sinais / MicroRNAs / Sumoilação Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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